Hi

Well
 1) If PD is a lack of dopamine in the brain ???
 2) If drugs can be delivered via the nose avoiding the blood/brain
barrier ???
 It follows that the best treatement for  PD is snorting dopamine !!
 I dont have a source of dopamine . But I tried snorting my L-dopa
first thing this morning . I was hoping for a faster response .

NO such luck . In fact it was far less than the normal swallowing .
It would seem that the nasal delivery of drugs to the brain is drug
and/or patient dependent . I am still wondering about snorting
dopamine itself . Also I am not exactly clear why the blood brain
barrier is avoided as I thought that that snorting was just a way of
delivering drugs to the blood in the head rather than to the blood in
the body . This is what made snorting a faster delivery of drugs to
the brain  .

> LONDON (September 2, 1998 2:31 p.m. EDT http://www.nandotimes.com) - Nose
> drops could transform the treatment of Alzheimer's disease and other illnesses
> that waste away the brain, New Scientist magazine reported Wednesday, citing
> recent research by a neuroscientist in Minnesota.
>
> The magazine said that the nasal passage, which provides a direct link to the
> brain, could be the ideal conduit for delivering therapeutic drugs that cannot
> reach the brain through the blood.
>
> The molecules of many drugs are so large they cannot cross the blood-brain
> barrier -- cells in the blood vessels in and around the brain that form a kind
> of barrier to guard brain tissue.
>
> Finding an effective method of delivering drugs directly to the brain has been
> a stumbling block in treating neurological diseases.
>
> The neuroscientist, William Frey of the Alzheimer's Research Center at the
> Regions Hospital in St. Paul, Minn., thought nose drops could be an ideal way
> to get a new treatment for the disease into the brain.
>
> "I knew that bad things could get in this way. It occurred to me that maybe
> good things could get in this way too," he said.
>
> He and his colleagues tested the theory on 12 rats. Half were given the
> treatment in nose drops and the rest in an injection. Within an hour of
> treatment Frey found that the treatment given in nose drops had reached the
> hippocampus, amygdala and other regions of the rats' brains not involved in
> smelling.
>
> In contrast, the rats that received injections had very little of the
> treatment in their brains. "The nose, they say, could deliver drugs not only
> for Alzheimer's disease but for a range of other neuro-degenerative conditions
> as well, including Parkinson's disease and multiple sclerosis," the weekly
> magazine said.
>
> Frey's team also used nose drops to administer insulin growth factor 1, a
> treatment for strokes, and found similar results. They will report their
> findings at a meeting of the American Association of Pharmaceutical Scientists
> in San Francisco in November.
>
> Copyright 1998 Nando.net
> Copyright 1998 Reuters News Service
>
> a new voice: http://www.newcountry.nu/pd/members/janet/index.htm
> 51/10 - almonte/ontario/canada - [log in to unmask]
> janet paterson
>
>
     peace
          Alastair     ( [log in to unmask] )