----------
> From: Sharon & Jim LeBlanc <[log in to unmask]>
> To: [log in to unmask]
> Subject: One Pathway where many things can go wrong to cause Parkinson's
Disease
> Date: Wednesday, February 17, 1999 10:49 AM
>
> < means decrease of substance
> > means increase of substance
>
>                                    URIC ACID    > protects against PD
>                                XANTHINE  Potent cAMP phosphodiesterase
> inhibitor
>                                     (GENE - Parkinsons produces too much
> cAMP)
>
>                   XANTHINE OXIDASE - converts hypoxanthine to xanthine to
> uric acid
>                             HYPOXANTHINE helps make adenosine
monophosphate
> (AMP)
>            ADENOSINE 5' (n-ethylcarboxamide)  Potent cAMP
phosphodiesterase
> inhibitor
>                                   (GENE - Parkinsons produces too much
> cAMP)
>
> Adenosine infusion reduces substance P in cerebrospinal fluid. cAmp is
> related to CREB related to dopamine. cAMP responsive gene proenkephalin
is
> part of the D2 receptor. Dopamine-receptor activation is related to CREB
> phosphorylation.
>
>            PERTUSSIS - inhibits the G-protein, causing loss of its
function
> and overproducing cAMP phosphodiesterase. It also causes Parkinson's
> disease.
>
>
> NAD - Nicotinamide adenenine dinucleotide is found in the retina.
> 4-HNE or 4-hydroxy-2-nonenal is also found in the retina. It is a product
> of lipid peroxidation. It causes a point mutation and defect of blue
color
> vision, tritanopia, a Parkinson's symptom.
>                             (GENE - 4HNE causes Parkinson's disease)
>      U-101033E works against 4-HNE and MDA or Malondialdehyde and will
help
> PD.
>
> NICOTINE is found in tobacco and tea, both protect against PD
> Nicotine is the N part of NAD
> Diethyldithiocarbamate or nicotine relates to n-ethylcarboxamide I
believe.
> Haven't found the proof yet.
> Sodium diethyldilithiocarbamate is related to Carbaryl, a pesticide.
>
> Carbaryl or 1-napthyl methylcarbamate is a wide spectrum insecticide
which
> controls over 100 species of insects on citrus, fruit, cotton, forests,
> lawns, nuts, ornamentals, shade trees as well as poultry, livestock and
> pets. It works whether ingested into the stomach of the pest or absorbed
> through direct contact. It is available ad bait, dust, wettable powders,
> granules, dispersions and suspensions. It is moderately to very toxic,
> effects the nervous system. It affects cell division and chromosomes in
> rats.
>
> Urethate or ethyl carbamate is a good solvent for organic materials, a
> co-solvent for pesticides, fumigants, medications (VET), ANESTHETICS,
> HYPNOTICS, SEDATIVES, diuretic solubilizer and co-solvent for cosmetics.
It
> is a co-solvent agent in textile treatments, an anti-neoplastic agent,
used
> as a component with quinine of sclerosing solutions, as a topical
> bactericide. It is colorless and odorless.
>
> Urethane is a co-solvent for pesticides, like rotenone that is NADH
> sensitive and has been shown to cause Parkinsons Disease.
>
> Normally, after the approptiate response is accomplished, cholinesterase
is
> released which breaks down acetylcholine, terminating the stimulation of
> muscle. If acetylcholinesterase is unable to break down or remove
> acetylcholine, the muscle can continue to move uncontrollably.
>
> Any pesticide can bind or inhibit cholinesterase, making it unable to
> breakdown acetylcholine. The two main inhibiting pesticides are
> organophosphates and the carbamates. Some newer chemicals, such as the
> chlorinated derivatives of nicotine can also effect the cholinesterase
> enzyme.
>
> Overexposure to organophosphate and carbamate insecticides can result in
> cholinesterase inhibition (EXTONET).
>
> Just my theory, but maybe a little nicotine raises n-ethylcarboxamide and
> prevents Parkinsons, but too much carbamates either mutates or destroys
> n-ethylcarboxamide and causes Parkinsons. I'm not a chemist.
>
> NADH - Co Q10
>
> NADH DEHYDROGENASE (COMPLEX I)
> Defect in Parkinson's disease (1993)
> (Rotenone)  - UQH2 (Ubiquinone) - FAD ( flavoprotein fragment of NADH)
> See Biochemical Pathways Map No O9 P9
>
> FAD - < Glutathione Reductase - < Glutathione - Protects against Lipid
> Peroxidation
>           Parkinsons is too much lipid peroxidation, these are too low.
>           (GENE - glutathione or glutathione reductase)
> FAD - < glutathione reductase - < alpha lipoic acid < dihydrolipoic acid
-
> < chelation of free metals
>           < ability to decarboxylate dopa to dopamine
>           (EDTA or chelation therapy preserves glutathione reductase)
> FAD- < Thioredoxin that thiolates glutamate synthase, peroxide reductase,
> nitrite reductase
>          > glutamate, peroxide, nitric oxide  (too much)
> FAD - A2Red - <P450, which is inhibited by 4-HNE, < CYP2D6
>           Responsible for protecting the body against toxins, hebicides,
> and through which 60% of all medications are metabolized.
>
>      (GENE) - CYP2D6 - Parkinsons
>      (GENE) - NDUFV2 - NADH mutation Parkinsons
>      (GENE) - NADH- ubiquinone oxioreductase depends on GRRed or
> glutathione reductase
>      (GENE) - APOE4 - Apolipoprotein - Too little lipids, too much
> peroxidation - Parkinsons
>      (GENE) - Alpha Synuclein - > Threonine - > lipid peroxidation -
> Parkinsons
>
> <Glutathione Peroxidase - > superoxide radicals - >SOD2 or superoxide
> dismutase two
> >SOD2 - >Manganese and Increased Manganese intake causes Parkinsons
>      (GENE) - SOD2
>
> >metals ->RHO - >Phospholipase D - >PIP2 - >IP3 - >Diacyglycerol -
> >Arachidonic Acid - >Phospholipase A which opens up the calcium channels.
>
> >diacyglycerol would inhibit Protein Kinase C which phosphorylates B
> vitamins, especially B6
> B6 deficiencies give you a lot of Parkinsons symptoms
> <B6 - <NIFS that chelates metal sulfur clusters. Can't break them up.
Lewy
> Bodies.
>
> <NADH - Complex I - <Ubiquitin E2-25K - <HIP2 - <Huntingtin -<Dynactin
p150
> or p50 -< CKAP - <Beta ACTIN - <NF/Y growth factor - (NFKB1 - Proteasome
> 26S)
>
> Stem cell stimulation stimulates OCT4 fibroblast growth factor,
stimulates
> POU, stimulates NFKB1 or Nuclear Factor Kappa B1.
>
>      (GENE) CCAAT binds to beta actin.
>
> [log in to unmask]