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> From: Sharon & Jim LeBlanc <[log in to unmask]>
> To: [log in to unmask]
> Subject: Second References forTheory of Environmental Parkinsons-
Pollutant Botulism - Clostridium Botulinum
> Date: Monday, July 05, 1999 1:36 PM
>
> 8. PMID 124040 - Cytochrome P450 (metabolizes retinoic acid) -
Full-length
> cDNA  genomic clone found to code for N-nitrosodimethylamine demethylase
> activity.
> 9. PMID 9050783 - Disruption of local retinoid-mediated gene expression
> accompanies abnormal development in the mammalian olfactory pathway.
> 10. Retinoid regulation of transglutaminase gene expression by Peter
Davies
> - CRISP RRE1 and HR-1 inhibit transglutaminase (Inhibition of Huntingtin
> may be a great treatment of  Huntingtons Disease)
> 11. PMID 602049 - RAS-Related C3 Botulinum Toxin (BOTOX) substrate RAC2
> displayed relative myeloid tissue selectivity. RAC1 and RAC2 are
substrates
> for ADP-ribosylation by C3 component of botulinum toxin. (ADP= adenosine
> diphosphate)
> 12. PMID 9252344 - Characterization of RAC3, a novel member of the RHO
> family - Rac1 and Rac2 are critically important in regulating multiple
> signal transduction pathways in eukaroytic cells. RAC3 is an active
GTPase,
> and this activity is regulated by Bcr (breakpoint cluster)
> 13. PMID 151410 Breakpoint Cluster region; Bcr.-  Chronic myeloid
leukemia
> is fundamentally a genetic disorder, specifically a somatic cell genetic
> disorder which has environmental causes shuch as irradiation and
chemical.
> 14. PMID 180240 Retinoic Acid Receptor, Alpha, RARA - Acute promyelocytic
> leukemia (APL) the breakpoints in 10 APL cases examined were shown to
> cluster in the 12-kb region of chromosome 17. See Wells 1997 and NUMA1
for
> discussion of a RAR/NUMA1 fusion protein associated with APL.
> 15. PMID 602124 Dystonia 7, Torsion; DYT7 - Typical spasmodic dysphonia
and
> responded with botulinum toxin. (Clostridium botulinum is anaerobic,
lives
> without oxygen,  forms nitrite, clostridium bryzantii is involved with
the
> oxidation of fatty acids. BOTOX prevents the release of chemical
> transmitters that activate muscles, and inhibits Acetylcholine) (BOTOX =
> shot of Parkinsons). (I think tremors are the muscles fighting the
> inhibition of acetylcholine, eventually they become rigid and painful,
then
> don't work at all.)
> 16. PMID 9733726 Inhibition of ribonuclease P by retinoids. All retinoids
> behave a classical competitive inhibitors.
> 17. PMID 9405615 Regulation of dopaminergic pathways by retinoids:
> activation of the D2 receptor promoter by members of the retinoic acid
> receptor-retinoid X receptor family.
> 18.PMID 9452386 Impaired locomotion and doamine signaling in retinoid
> receptor mutant mice
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