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> From: Sharon & Jim LeBlanc <[log in to unmask]>
> To: [log in to unmask]
> Subject: Third References for Theory of Environmental Parkinsons -
Pollutant Botulism - Clostridium Botulinum
> Date: Monday, July 05, 1999 2:40 PM
>
> 19. PMID 123810 Cyclic AMP response element - binding protein CREB1 -
> Stimulates transcription of an array of cAMP (Adenosine Monophosphate)
such
> as proenkephalin and FOS. CREB1 may be identical to activating
> transcription factor (ATF).  Taylor mapped CREB1 to 2Q34,3-Q34 and
> speculated the possible involvement in genetic disorders or cancer,
pointed
> to the fact that TCL4, a locus implicated in T-cell leukemia/lymphoma is
> located 2q34. (Proenkephalin - enkephalin- D2 dopamine receptors).
> 20. Ligand Pharmaceuticals - 1999 - LGD1069 - Recently, 9-cis-retinoic
> acid, a high affinity ligand for retinoic acid receptors and retinoid
> X-receptors (RXR) was shown to have efficacy superior to all-trans
retinoic
> acid as a chemopreventive agent in the N-Nitroso-N-methylurea induced rat
> mammary carcinoma. (Breast Cancer). Cutaneous T-cell lymphoma (CTCL).
> (Targretin capsules are under orphan drug designation.)
> 21. PMID 600825 RAR-Related orphan receptor ALPHA, Retinoic Acid-Binding
> receptor ALPHA (Alpha,Beta,Gamma)
> 22. PMID 9884583 Vitamin A functions in the regulation of the
dopaminergic
> system in the brain and pituitary gland -  D2R knockout mice lack these
> retinoic acid receptors and exhibit a defect in locomotion similar to
that
> seen in Parkinsons disease.
> 22. C/EBPE - Study of a novel Myeloid Transcription Factor  by Koeffler,
> Philip H. - C/EBP, a CCAAT enhancer binding protein that is a frequent
> partner of CREB2. It is a human myeloperoxidase promoter. (Parkinsons is
an
> overproduction of lipid peroxidation. PARK 1,2,3 Parkinsons genes, alpha
> synuclein, produce too much threonine that increases lipids and lipid
> peroxidation into the brain. It is similar to Huntingtons disease that
> introduces too much glutamine into the brain. Glutamine binds with
> Huntingtin, a transglutaminase , that is effected by CCAAT- or CUTL1 or
> Caspase-1 that cuts the huntingtin protein  making globs that cause
> Huntingtons brain cells to die.)
> 23. PMID 180220 Retinoic Acid Receptor , BETA, RARB - HAP (HBV-activated
> protein) is a retinoic acid receptor. (HAP1 binds with Huntingtin. HIP2
or
> Huntingtin-associated protein binds with HAP1which binds with dynactin
P50
> and dynactin P150 that binds to centractin, and F-actin . HIP-2 or E2-25K
> or ubiquitin-conjugating enzyme is part of Complex I, NADH-Ubiquinone
> (CoQ10)).
> 24.  PMID 9932947 -AAT Alpha-1-gene mutation Alzheimers Disease. AAT
> overrepresentation in Parkinsons disease. AAT and Transglutaminase bind
> with prealbumin found in amyloid fibers of Alzheimers (Maybe Lewy Body
> Parkinsons)
> 25. PMID 180231Retinoic acid-binding protein CRAB2 linked to muscle
> nicotinic acetylcholine receptor alpha-chain (Acra) and catalase-1
(CAS-1).
> 26. Transcriptional regulation of cell growth. by Verma, Inder M. - CRISP
-
> Retinoids repress transcription by early response genes like Fos, Jun,
and
> NF-KappaB/Rel. Control of cellular proliferation by cAMP.
> (Pertussis-Parkinsons) (ethyl-carbamate)
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