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> From: Sharon & Jim LeBlanc <[log in to unmask]>
> To: [log in to unmask]
> Subject: Fourth References for Theory of Environmental Parkinsons -
Pollutant Botulism - Clostridium Bodulinum
> Date: Monday, July 05, 1999 3:21 PM
>
> 27. Biology and Pathology of a modulator of FGF by Wellstein, Anton -
CRISP
> - fibroblast growth facto (Stem Cells) is mobilized by binding to a
> secreted binding protein for FGF(BP). Retinoids downregulate BP mRNA.
(Why
> stem cell stimulation and GDNF or glial-derived growth factor works for
> Parkinsons)
> 28. RXR/PPAR regulated expression in adipocytes by Ahuja, Harleen S. -
> CRISP - RXR-specific ligand can produce an acute effect in 3T3-L1
> differentiated adipocytes. (APOE4 apoprotein, apolipoprotein genetic
> Parkinsons).
> 29. Journal of Neurochemistry - Nicotine prevents experimental Parkinsons
> in rodents and induces striatal increases of neurotrophic
> factors.Diethyldithiocarbamate (ethyl carbamate) a caspase inhibitor
> enhanced 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine or MPTP toxicity.
> MPTP toxicity from synthetic demerol caused Parkinsons disease in those
who
> took the drug. Effecting NMDA receptors.
> 30. Retinoid Signaling Pathways by Jetten, A. Actions of certain
retinoids
> not mediated by RAR and RXR retinoid receptors such as AHPN.
Overexpression
> of lymphoma cells is accompanied by caspase-3 activity. SVAD-fmk
inhibited
> cell death but did not affect induction of growth arrest. ZVAD-fmk was
used
> as a trial to inhibit Caspase-1 in Huntington's disease. AHPN or
> 6-3-1-adamantyl-4-hydroxy-phenyl-2-naphthalene-carboxylic acid would be
> metabolized by the tricarboxylic acid cycle, cAMP,CREB,CREB2,CCAAT.
> 4HNE mutation causes Parkinsons disease. PMID 8687011 Accumulation of
> deletions and point mutations in mitochondrial genome in degenerative
> diseases.
> 31. Interaction between the components of the human NADPH oxidase: A
review
> about the intrigues in the PHOX family - Emma's Children Hospital,
Academic
> Medical Center, Amsterdam, The Netherlands. Rap1 becomes phosphorylated
by
> the cAMP dependent PKA . A serine residue at the COOH-terminal region of
> RAP1A has been identified as a site of phosphorylation by PKA. It is
> possible that phosphorylation of Rap1A regulates the deactivation of
NADPH
> oxidase. Rap1 effects cytochrome b 558. NADPH oxidase is a rasrelated
> protein called rac.
> 32.PMID 602048 Ras-related C3 Botulinum Toxin substrate; RAC1 regulates
> cell growth, cytoskeletal reorganization, and the activation of protein
> kinases. Rac1 and Rac2 idntify with RHOS and RAS respectively. The 2
genes
> encode the C-terminal consensus sequence (CXXX-COOH). Rac1 is essential
for
> nuclear factor kapaB/rel-dependent transcriptional regulation of
> interleukin-1-alpha, which in an autocrine manner, induced collagenase-1
> gene expression.
> 33. PMID 6952245 Cloned cDNA sequences of the hypoxanthine/guanine
> phosphoribosyltransferese gene from mouse neuroblasotma cell line found
to
> have amplified genomic sequences. (HPRT gene color blindness - increased
> HPRT protein)
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