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> From: [log in to unmask]
> To: [log in to unmask]
> Cc: [log in to unmask]
> Subject: Parkinsons Disease and Environmental Botulism
> Date: Sunday, July 04, 1999 11:58 AM
>
> I am writing to you because your name was given to me by our MD who said
> you were connected with the Harvard Health Letter. There is a disease
> where muscles grind to a halt, the eyelids droop, then it becomes more
> and more difficult to swallow, and to breathe and then you die. Sounds
> like Parkinsons, but its botulism. Clostridium botulinum lives in the
> soil, it makes nitroso, dimethylbutyrate, amines that live in sludge and
> sewers and old smoked food. N-nitrosodimethylamine and dimethylamine
> that becomes N-nitrosodimethylamine in air are found in diesel and gas
> exhaust, pesticide propellant, food, meat packaging, infant formula, and
> many other places. They are a cRA or 13-cis-retinoid that has caused
> craniofacial mutation in animals. Clostridium botulinum effects
> breakpoint clusters that happen when there is an environmental cause of
> a genetic disease. N-nitrosomethylurea causes breast cancer.
> Parkinsonians often have craniofacial birth defects like blue-yellow
> color blindness and olfactory (an unusual smell of which they can
> predict future parkinsonians in families). My husband has Parkinsons.
> His fraternal twin has breast cancer. I think I have found the
> environmental cause of Parkinsons disease. The other reason I am
> writing, is that retinoid X mutant mice have a parkinsonian locomotion
> and Targretin is a new drug put out by Ligand Pharmaceuticals for breast
> cancer, diabetes type two, often associated with Parkinsons, which my
> husband has, and for psoriasis which my husband has. I think he really
> needs the retinoid CREB2, but this targretin would help for now, and the
> company has other retinoid drugs in the works. The company has no plans
> to try it for Parkinsons. From what I understand, Parkinsons is an
> overproduction of cAMP which the retinoid CREB inhibits, and it is an
> overproduction of lipid peroxidation which CREB2 would inhibit since it
> is often associated with C/EBP or the myeloperoxidase promoter. They are
> using BOTOX treatments for dystonia in parkinsons.  I think they are
> giving Parkinsons shots really , more N-nitrosodimethylamine to really
> kill the muscle and deaden the effects of acetylcholine. It does help
> the pain and spasms. Slowly the brain cells are dying and there is less
> CREB2. Also butyrate increases tumor formation, maybe lewy bodies.
> Dimethylamine inhibits Transglutaminase activity that connects to AAT,
> and there is an AAT Parkinsons disease. Dimethylamine also inhibits
> glucose-stimulated insulin release, causing diabetes type two, and
> amines form complexes with metallic ions, maybe this might explain
> Alzheimers and aluminum, Parkinsons and a low zinc level. Parkinsonians
> also have elevated T-cells.  I have scientific papers at home to back
> this up. We live outside of Boston. Thanks for listening.
> [log in to unmask]