Sorry for asking but do receptors "release"?

Maryse

Sharon & Jim LeBlanc a écrit:

> (Parkinsons Disease by Christopher Johnson)
> There are D1 receptors on striatal neurons which release a combination of
> the neurotransmitters GABA and substance P. When the D2 receptors bind
> dopamine these neurons emit tonic inhibitory output to the external globus
> palidus, which itself has tonic inhibitory projections to the subthalamic
> nucleus.
> Requip binds to D1 and D3 dopamine receptors.
> Mirapex prefers the D3 receptor.
> D3 receptors are associated with opiate dependence (Pub Med - Homozygosity
> of the dopamine D3 receptor)
> Elevated levels of substance P have been described in fibromyalgia which is
> a syndrome of widespread pain and sleep disturbance.
> (Relationship of substance P and tryptophan - Pub Med) (Substance P is
> related to pain)
> GABA - B inhibits substance P. (Gama-aminobutyric acid B - Pub Med)
> Gamma-hydroxybutyric acid is used to treat Narcolepsy. (Pub Med)
> Analysis of the monoamine oxidase genes and the Norrie disease gene locus
> in Narcolepsy.
> Methamphetamines increase substance P and cause dystonia and are used to
> treat Narcolepsy.
> Isoniazid is well known to increase concentrations of gamma-aminobutyric
> acid (GABA), and to relieve dystonia.
>
> SO let me see if I get this right.
> If you decrease Gaba too much and increase substance P, you will get
> dystonia and be wide awake.
> If you increase Gaba and inhibit substance P too much you will get
> Narcolepsy but feel great.
> Parkinsons has too much dopamine not converted to dopa. The dopamine
> inhibits GABA and you get dystonia and can't sleep .
> Parkinsons has not enough monoamine oxidase inhibitors, and when you don't
> have any like Norrie disease you get Narcolepsy.
>
> This is just my opinion, but Mirapex and Requip increase (R)Salsolinol.
> That is why they help. And it looks like they increase Gaba.
> You naturally make N-Methyl in your intestines. Eventually you get N-Methyl
> (R) Salsolinol which causes Parkinsons.
> (Analgesic effects of 3-carboxysalsolinol alone and in combination with
> morphine ) Suggests an interaction with central opiate receptors. Central
> opiate receptors are D3. Mirapex and Requip boost D3. Why don't
> parkinsonians just take GABA that you can buy over the counter for sleep. I
> would think it would help the dystonia without all the side effects. Then
> again I don't know if it is GABA-A or GABA-B. All I know is that it does
> work for sleep.
>
> Also, Mirapex which has a benzathiazol concerns me since the
> 1-benzy-tetrahydroisoquinolines interact with the alpha-adrenergic
> chromaffin cells. Botox neurotoxin for dystonia effects SNAP-25 of the
> chromaffin cells. It reduces epinephrine and norepinephrine.
>
> Elevated norepinephrine has been shown to cause dystonia.(Dyskinesias
> possibly induced by norpseuto4ephedrine)- Pub Med.
> Ephedrine stimulates the hormone norepinephrine.
>
> Just putting things together. Thanks for listening.
>
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