Hi Joe: Interested in these alternative delivery
systems for levodopa. Can you post some references?
                    Carole H.

--- "J. R. Bruman" <[log in to unmask]> wrote:
> ARNE KARLSSON wrote:
> > My problem is that protein in the food block the
> L-dopa uptake from
> > the intestines  and I have many and deep
> OFF-periods during the day.
>
> Levodopa absorption
> Oct 99
> Arne, here are some things I do for the same
> problem:
> - Try to take levodopa dose when stomach is empty,
> along
>   with plenty of water to ensure it reaches small
> intestine
>   ahead of food.
> - Try to confine major protein components to last
> meal before
>   bedtime, and wait a half hour or so for the
> stomach to
>   empty (hopefully) before the evening medication.
> - When you can't avoid taking levodopa just before
> or just
>   after eating, don't swallow it immediately but let
> it
>   dissolve partly in your mouth. There is some
> absorption
>   through the mouth lining.
> - (ask your doctor first): Levodopa that fails to be
> absorbed
>   in the small intestine just passes through
> harmlessly.
>   Therefore an extra dose occasionally when you're
> "off" should
>   be helpful and not harmful.
> - Research is underway for delivering levodopa other
> than by
>   mouth: hypodermic injection; adhesive skin patch;
> attached
>   pump with permanent tube to intestine (available
> now). None
>   of these sounds very attractive to me, but perhaps
> when the
>   PD gets bad enough I'll change my mind. Cheers,
> Joe
>
> --
> J. R. Bruman   (818) 789-3694
> 3527 Cody Road
> Sherman Oaks, CA 91403-5013
>


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