Roberta

I don't take any MAO inhibitors or much else so the tyrosine is most likely 
OK for me.  thanks for clarifying the issue.  It would be great if I could 
lose some fat.
Ray
Rayilyn Brown
Director AZNPF
Arizona Chapter National Parkinson Foundation
[log in to unmask]

--------------------------------------------------
From: <[log in to unmask]>
Sent: Sunday, May 10, 2009 8:23 AM
To: <[log in to unmask]>
Subject: Re: Question re milk thistleand tyrosine

>
>
> The following taken from "Prescription for Nutritional Healing" Third
> Edition:
>
> "Tyrosine is important to overall metabolism.  It is a precursor  of
> adrenaline and the neurotransmiters norepinephrine and dopamine, which 
> regulate
> mood and stimulate metabolism and the nervous system.   Tyrosine acts as a
> mood elevator; a lack of adequate amounts of tyrosine  leads to a 
> deficiency
> of norepinephrine in the brain, which in turn can  result in depression. 
> It
> also acts as a mild antioxidant, suppresses  the appetite, and helps to
> reduce body fat.  It aids in the  production of melanin (the pigment 
> responsible
> for skin and hair color)  and in the functions of the adrenal, thyroid, 
> and
> pituitary glands.   It is also involved in the metabolism of the amino 
> acid
> phenylalanine.
>
> Tyrosine attaches to iodine atoms to form active thyroid  hormones.  Not
> surprisingly, therefore, low plasma levels of tyrosine  have been 
> associated
> with hypothyroidism.  Symptoms of tyrosine  deficiency can also include 
> low
> blood pressure, low body temperature (such  as cold hands and feet), and
> restless leg syndrome.
>
> Supplemental L-tyrosine has been used for stress reduction, and  research
> suggests it may be helpful against chronic fatigue and  narcolepsy.  It 
> has
> been used to help individuals suffering from  anxiety, depression, low sex
> drive, allergies, and headaches, as well as  persons undergoing withdrawal
> from drugs.  It may also help people  with Parkinson's disease.
>
> Natural resources of tyrosine include almonds, avocados, bananas,  dairy
> products, lima beans, pumpkin seeds, and sesame seeds.   Tyrosine can also 
> be
> produced from phenylalanine in the body.   Supplements of L-tyrosine 
> should
> be taken at bedtime or with a  high-carbohydrate meal so that it does not
> have to complete for absorption  with other amino acids.
>
> Persons taking monoamine oxidase (MAO)) inhibitors, commonly  prescribed
> for depression, must strictly limit their intake of foods  containing 
> tyrosine
> and should not take any supplements  containing L-tyrosine, as it may lead
> to a sudden and dangerous rise in  blood pressure.  Anyone who takes
> prescription medication for  depression should discuss necessary dietary
> restrictions with his or her  physician."
>
> I take Azilect which is an MOA (B) not (A) inhibitor so I don't know  if
> the last paragraph would apply as I obviously don't take it for 
> depression
> but for PD.  I guess I'll need to research further unless  anyone on this
> forum knows the answer.
>
> Roberta Innarella
>
>
> In a message dated 5/10/2009 3:27:33 A.M. Eastern Daylight Time,
> [log in to unmask] writes:
>
> Schaff:
>
> I ordered 1000 msg milk thistle and 500 msg  L-tyrosine - is that the
> correct
> amount or not?
> thanks so much  and for clarifying the bp issue.  I  couldn't find 
> anything
>
> on line that said tyrosine caused high bp - and yes it did claim  these 2
> supplements as treatment for PD.  thanks so very  much
>
> here's hoping....I don't take PD meds you know, but am  getting worse
>
> Ray
>
> Rayilyn Brown
> Director  AZNPF
> Arizona Chapter National Parkinson  Foundation
> [log in to unmask]
>
> --------------------------------------------------
> From:  "Schaaf Angus / Meadow Creek Ranch" <[log in to unmask]>
> Sent:  Sunday, May 10, 2009 8:09 PM
> To:  <[log in to unmask]>
> Subject: Re: Question re milk  thistleand tyrosine
>
>> To the best of my knowledge tyrosine has  no impact on blood pressure. It
>> is
>> a precursor  necessary for the production of dopamine by the liver. It is
>>  quite beneficial. Salt and sugar as well as poor diets have more impact
> on
>> BP .
>> Hope this helps.
>> If it werent for  tyrosine in my program I couldnt do the 5 to 6 hours of
>> walking  I've been doing the last few days fixing storm damage on the
> ranch
>> fences. Needless to say by sundown I'm really wornout for  the day.
>> Have a good Sunday Ray.
>>
>> ----- Original  Message -----
>> From: "rayilynlee"  <[log in to unmask]>
>> To:  <[log in to unmask]>
>> Sent: Friday, May 08, 2009  10:48 AM
>> Subject: Re: Question re milk  thistle
>>
>>
>>> thanks Roberta  - I take bp  medication
>>> Ray
>>>
>>> Rayilyn  Brown
>>> Director AZNPF
>>> Arizona Chapter National  Parkinson Foundation
>>>  [log in to unmask]
>>>
>>>  --------------------------------------------------
>>> From:  <[log in to unmask]>
>>> Sent: Thursday, May 07, 2009 4:03  AM
>>> To: <[log in to unmask]>
>>>  Subject: Re: Question re milk thistle
>>>
>>>  >
>>> >
>>> > Doesn't Tyrosine increase blood  pressure?
>>> >
>>> > Roberta  Innarella
>>> >
>>> >
>>> > In a  message dated 5/7/2009 2:01:57 A.M. Eastern Daylight Time,
>>>  > [log in to unmask] writes:
>>> >
>>> >  Yep!
>>> >
>>> > ----- Original Message  -----
>>> > From:  "rayilynlee"  <[log in to unmask]>
>>> > To:   <[log in to unmask]>
>>> > Sent: Tuesday,  May 05, 2009  9:45 AM
>>> > Subject: Re: Question re  milk thistle
>>> >
>>> >
>>> >> gee,  I  didn't know milk thistle would help my liver produce
> dopamine.
>>> >> I
>>> >> started taking it  for constipation.  Do I need to take  tyrosine 
>>> >> with
>>  it?
>>> >>
>>> >> Ray
>>>  >>
>>> >> Rayilyn  Brown
>>> >>  Director AZNPF
>>> >> Arizona Chapter National  Parkinson  Foundation
>>> >>  [log in to unmask]
>>> >>
>>> >>   --------------------------------------------------
>>> >>  From: "Schaaf  Angus / Meadow Creek Ranch"  <[log in to unmask]>
>>> >> Sent:  Tuesday, May  05, 2009 8:40 AM
>>> >> To:   <[log in to unmask]>
>>> >> Subject:  Question re  Amantadine/  GSH importance
>>>  >>
>>> >> > Couple of  thoughts.
>>>  >> > Have you tried to let your liver produce your   dopamine needs by
>> taking
>>> >> > tyrosine and  milk thistle?
>>> >>  > The natural production of  GSH  by the body is a little more
>>> >  complicated
>>> >> > but
>>> >> >  following is article from my  archives that helps  explain.
>>> >> >      WHY   GSH
>>> >> > Oxidative stress appears to play an  important role in 
>>> >> > degeneration
>> of
>>> >>  > dopaminergic neurons of the substantia  nigra (SN) associated 
>>> >> with
>>> >> > Parkinson's disease (PD). The SN  of  early PD patients have
>>> >> >  dramatically
>>> >> > decreased levels of  the  thiol tripeptide glutathione (GSH). GSH
>> plays
>>>  >> > multiple  roles in the nervous system both as an  antioxidant and 
>>> a
>>> >> > redox
>>>  >>  > modulator. We have generated dopaminergic PC12 cell  lines in
> which
>>> > levels
>>> >> >  of
>>> >> > GSH can be inducibly  down-regulated  via doxycycline induction of
>>> > antisense
>>>  >> >  messages against both the heavy and light subunits  of
>>> >> >  gamma-glutamyl-cysteine synthetase,  the rate-limiting enzyme in
>>> >>  >  glutathione
>>> >> > synthesis. Down-regulation  of  glutamyl-cysteine synthetase 
>>> >> > results
>> in
>>>  >> > reduction in  mitochondrial GSH levels, increased  oxidative
> stress,
>> and
>>> >> >  decreased  mitochondrial function. Interestingly, decreases in
>>>  >>  > mitochondrial
>>> >> > activities  in GSH-depleted PC12 cells  appears to be because of a
>>>  > selective
>>> >> > inhibition of  complex I  activity as a result of thiol oxidation.
>> These
>>>  >> >  results suggest that the early observed GSH losses  in the SN may
>>> >> > be
>>> >> >  directly
>>> >> > responsible for the noted   decreases in complex I activity and the
>>> >> >  subsequent
>>> >>  > mitochondrial dysfunction,  which ultimately leads to dopaminergic
>>> >>  cell
>>> >> > death
>>> >> >  associated with PD.
>>> >>  >
>>> >>  >   WHY GLUTAMINE
>>> >> > Glutamine is  an  important mitochondrial substrate implicated in
> the
>>>  >> >  protection of cells from oxidant injury. Human  pulmonary
>>> > epithelial-like
>>> >> >  (A549) cells were exposed to 95% O(2) for 4  days in the absence
> and
>>> >> > presence
>>> >> > of  glutamine.  Cell proliferation in normoxia was dependent  on
>>> > glutamine,
>>> >> >   and
>>> >> > glutamine deprivation markedly accelerated  cell death  in
> hyperoxia.
>>> >> > Glutamine  significantly increased cellular  ATP levels in normoxia
>>  and
>>> >> > prevented the loss of ATP in   hyperoxia seen in glutamine-deprived
>>> > cells.
>>>  >> > Mitochondrial  membrane potential as assessed by flow  cytometry
> with
>>> >> >   chloromethyltetramethylrosamine was increased by glutamine  in
>>> >>  > hyperoxia-exposed A549 cells, and a  glutamine dose-dependent
>> increase
>>> >  in
>>> >> > mitochondrial membrane potential was  detected.
>> Glutamine-supplemented,
>>> >> >  hyperoxia-exposed cells had a  HIGHER  O(2) consumption rate  and
> GSH
>>> >> > content.
>>> >>   > Electron and fluorescence microscopy revealed that, in
> hyperoxia,
>>> >> > glutamine
>>> >> >  protected cellular  structures, especially mitochondria, from
>>> >> > damage.
>>> >> >  In
>>> >> >  hyperoxia, activity of the  tricarboxylic acid cycle enzyme
>>> >> >   alpha-ketoglutarate dehydrogenase was partially protected by 
>>> >> > its
>>> > indirect
>>> >> > substrate,  glutamine, indicating a  mechanism of mitochondrial
>>>  > protection.
>>> >> > THEREFORE:   I take  L-Glutamine and DHEA to increase the level of
>>> >> >  GSH
>>> >> > in
>>> >> >   the
>>> >> > body naturally to further thwart the  symptoms and  destruction of
>> P.D.
>>> >> >  along
>>> >> > with my other  vitamin/mineral  protocol which exclude PD drugs. As
> a
>>> > note.
>>>  >>  > I
>>> >> > never tried the  Amantadine. My doctors forced me  early to look
>>> >  elsewhere
>>> >> > for
>>> >> > help  since they  couldnt due to lack of knowledge or incentive.
> Not
>>> >> > sure
>>> >> >  which  but I'm alot healthier for switching to a no drug
> protocol.
>>> >> >
>>> >> > -----  Original Message -----
>>> >>  > From: "Ernesto  Divo" <[log in to unmask]>
>>> >> > To:   <[log in to unmask]>
>>> >> > Sent:  Sunday, May 03,  2009 12:24 PM
>>> >> > Subject:  Re: Question re Amantadine  use
>>> >>  >
>>> >> >
>>> >> >> Hi  John,
>>> >>  >>
>>> >> >>  I'm 56 and was diagnosed with PD in 2000, I've  been taking
> Azilect
>>> >> >> and
>>> >> >>  Requip (Ropinirole) the nausea  form the Requip is  unbearable. 
>>> >> >> I
>> have
>>> >> >>  introduced  to my regimen for the past 5 months or so, 'MaxGXL',
> a
>>> >> >  supplement
>>> >>  >> developed here in the US, by a US scientist  and sold by a  US
>>> >> >> company. It raises thet levels of  GSH  in your cells naturally. 
>>> >> >> It
>>> >> >>  took
>>> >> >> the
>>> >>  >>  GXL about a week to work on my sleeping pattern, I was  waking 
>>> >> up
>> 2-3
>>> >> >> times
>>>  >> >> during the night, now I  sleep straight thru the  night, and it
> took
>>> > about
>>> >>  >>  three weeks to work on my cognitive process but it was so
> subtle
>>> >> >> I
>>> >  barely
>>> >> >> thought it was the GXL. I wasn't  having  problems looking for
> words
>> to
>>> >>  > finish
>>> >> >> a  sentence, my memory is  back, I don't lose things around the
>> house,
>>> >  I
>>> >> > have
>>> >> >> more  energy and I feel good and my  wife is happier.  It is
>>> >> >> strange,
>>> >  when
>>> >> >> I
>>> >>  >>  asked my doctor about it he said Gluta what?  it seems the
>>> >> medical
>>> >> >  community
>>> >> >> is keeping the use of   Glutathione (GSH) under wraps, they don't
>> want
>>>  >> >>  competition...  I order mine from  www.maxgxl.com/133282  I
>>> >> >>  suggest
>>> >> >> getting
>>> >>  >> as much info as  possible of GSH, I went to  www.youtube.com and
>>> > searched
>>> >>  >  for
>>> >> >> 'The mother of all  antioxidants', there is this  doctor Mark 
>>> >> >> Hyman
>>  who
>>> >> >> explains in details about GSH;   excellent video.
>>> >> >>
>>> >>  >> Good luck to  you.
>>> >>  >>
>>> >> >> Ernesto,
>>> >>  >> Miami,  FL
>>> >> >>
>>>  >> >> On Sat, May 2, 2009 at 11:46 AM,  john  emrys
>> <[log in to unmask]>
>>> >> >  wrote:
>>> >>  >>
>>> >> >>  > Hey John
>>> >> >> >
>>>  >>  >> > I've been on Amantadine since being  diagnosed in October  of
>>> >> last
>>>  > year;
>>> >> >> > dosage has remained  constant and  titrated from 100mg to 300mg
>>> >>  >> > per
>>> > day,
>>> >> >  over
>>> >>  >> > an initial period of 3  weeks.
>>> >> >>  >
>>> >>  >> > I space the dosing about 5-ish hours apart;  I've  found if the
>> final
>>> >> >> >  dose
>>> >> >  of
>>> >> >>  > 100mg is taken later than 8PM, I have trouble  sleeping 
>>> >> >> through
>> the
>>> >> > night.
>>>  >> >> >
>>> >>  >> > It does  give me an energy boost and some minor relief from
>>  muscle
>>> >> >> > tightness, but does nothing to  improve gait  or reduce tremor.
>> It's
>>> >  sort
>>> >> > of
>>> >> >>  >  just a little bit of "gas" for your "engine."
>>>  >> >>  >
>>> >> >> > On the  other hand, I find it causes auditory  hallucinations,
>>>  >> >> > drowsiness,
>>> >> >>  >  occasional vertigo, foggy thought processing and swelling
> around
>>> > the
>>> >> > knees.
>>>  >> >> >
>>> >> >> > I  find  much better results on GSH and mucuna bean, which I
>>  started
>>> >>  >> > about
>>>  >> > 6
>>> >> >> > months ago (the   mucuna has been a very recent thing, so it's
>>> >>  >> > been
>>> > too
>>> >> >   early
>>> >> >> > to tell – but so far, I'm  definitely  impressed). My neuro
>>> >  practically
>>> >> > lit
>>> >> >>  >  his own hair on fire when I told him, but he couldn't  deny
> the
>>> > results
>>> >> >  of
>>> >> >> > the GSH.
>>>  >>  >> >
>>> >> >> > The goal  is to be able to cut the  amantadine by 35 - 50%
> within
>>> >> >> > 6
>>> >> >  months.
>>> >> >>  > My view is the longer I  stay away from starting the agonists,
>> the
>>> >>  > better.
>>> >> >> >
>>> >>  >> >  Hope that helps.
>>> >> >>  >
>>> >> >> >
>>> >>   >> >
>>> >> >> > Joh
>>>  >> >> >
>>> >>  >>  >
>>> >> >>
>>>
>>>  >>  >
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