Part Two of MEDLINE on PD and childhood diseases, influenza, and
environmental exposures.
 
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DIALOG(R)File 154:MEDLINE(R)
(c) format only 1995 Knight-Ridder Info. All rts. reserv.
 
07524547   91043547
  Hemiparkinsonism-hemiatrophy   syndrome:   clinical  and
neuroradiologic
features.
  Giladi N; Burke RE; Kostic V; Przedborski S; Gordon M; Hunt A; Fahn S
  Neurological  Institute,  College  of Physicians and Surgeons of
Columbia
University, New York, NY.
  Neurology (UNITED STATES)   Nov 1990,  40 (11) p1731-4,  ISSN
0028-3878
Journal Code: NZ0
  Contract/Grant No.: R-29 NS26836, NS, NINDS
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 9102
  Subfile:   AIM; INDEX MEDICUS
  We  evaluated 11 patients with hemiparkinson-hemiatrophy syndrome, 6
with
body  and  contralateral cerebral hemispheric hemiatrophy, 4 with only
body
hemiatrophy,  and  1  with  just brain hemiatrophy. The mean age of
symptom
onset was 38.1 years (range, 18 to 54) with 5.2 +/- 3.1 (mean +/- SD)
years
of  illness  until  the  last  follow-up  visit. The presenting symptom
was
unilateral tremor in 6 patients, hand dystonia in 2, bradykinesia in 2,
and
abnormal gait in 1 patient. Three patients had a good response to
levodopa,
4  had moderate response, and 2 patients had a poor response. During a
mean
follow-up  period  of 1.7 years (range, 4 months to 5 years), the Hoehn
and
Yahr  score  changed in only 3 patients: 2 gained 1.5 points and 1
gained 3
points    over    2.5   years.   We   discuss   the   association
between
hemiparkinsonism-body    hemiatrophy    and    contralateral
hemispheric
hemiatrophy, and raise the possibility of early childhood brain insult
with
delayed-onset parkinsonism.
  Tags:  Female; Human; Male; Support, Non-U.S. Gov't; Support, U.S.
Gov't,
Non-P.H.S.; Support, U.S. Gov't, P.H.S.
  Descriptors:      *Brain--Pathology--PA;
*Extremities--Pathology--PA;
*Parkinson Disease, Symptomatic--Diagnosis--DI; Adolescence; Adult;
Atrophy
; Brain--Radiography--RA; Follow-Up Studies; Levodopa--Therapeutic
Use--TU;
Magnetic  Resonance  Imaging;  Middle  Age;  Parkinson Disease,
Symptomatic
--Drug   Therapy--DT;    Parkinson  Disease,
Symptomatic--Radiography--RA;
Retrospective Studies; Syndrome; Tomography, X-Ray Computed
  CAS Registry No.: 0   (Levodopa)
 
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(c) format only 1995 Knight-Ridder Info. All rts. reserv.
 
06407280   88052280
  Environmental factors in the etiology of Parkinson's disease.
  Tanner CM; Chen B; Wang WZ; Peng ML; Liu ZL; Liang XL; Kao LC; Gilley
DW;
Schoenberg BS
  Department of Neurological Sciences, Rush-Presbyterian-St. Luke's
Medical
Center, Chicago, IL.
  Can  J  Neurol  Sci (CANADA)   Aug  1987,  14  (3  Suppl)  p419-23,
ISSN
0317-1671   Journal Code: CJ9
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
  JOURNAL ANNOUNCEMENT: 8803
  Subfile:   INDEX MEDICUS
  Parkinson's disease (PD) has been proposed to result from the
interaction
of  aging  and environment in susceptible individuals. Defective
metabolism
of  debrisoquine,  inherited as an autosomal recessive, has been
associated
with this susceptibility. In 35 PD patients and 19 age-matched controls,
no
significant  differences  in debrisoquine metabolism were found,
although a
trend  to impaired metabolism was noted in patients with disease onset
less
than  or equal to 40. Foci of PD patients were associated with rural
living
and  well  water drinking, or rural living coupled with market gardening
or
wood  pulp  mills.  In  a questionnaire survey, patients with PD onset
less
than  or  equal  to  age 47 were significantly more likely to have lived
in
rural areas and to have drunk well water than those with onset greater
than
or  equal  to  age 54 (p less than or equal to 0.01). Because of
population
mobility   in   North  America,  a  case-control  study  designed  to
test
environmental, occupational, dietary and other proposed risk factors for
PD
was  conducted  in  China,  where the population is more stationary and
the
environment  more  stable. No significant differences in incidences of
head
trauma,  smoking  or  childhood  measles  were  found  between patients
and
controls.  (47 Refs.)
  Tags: Female; Human; Male; Support, Non-U.S. Gov't
  Descriptors: *Environment; *Parkinson Disease,
Symptomatic--Etiology--ET
;   Adult;   Environmental   Pollution--Adverse  Effects--AE;  Middle
Age;
Parkinson Disease, Symptomatic--Chemically Induced--CI;  Parkinson
Disease,
Symptomatic--Genetics--GE;  Rural Population; Smoking--Adverse
Effects--AE;
Stress--Complications--CO
 
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06407279   88052279
  Geography,  drinking  water  chemistry, pesticides and herbicides and
the
etiology of Parkinson's disease.
  Rajput  AH;  Uitti RJ; Stern W; Laverty W; O'Donnell K; O'Donnell D;
Yuen
WK; Dua A
  Department   of  Clinical  Neurological  Sciences,  University
Hospital,
Saskatoon, Saskatchewan, Canada.
  Can   J  Neurol  Sci (CANADA)   Aug  1987,  14  (3  Suppl)  p414-8,
ISSN
0317-1671   Journal Code: CJ9
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 8803
  Subfile:   INDEX MEDICUS
  In  1984 we made the first observation of a correlation between early
age
exposure  to rural environment (and drinking well water) and development
of
idiopathic  Parkinson's  disease  (IPD).  These  findings were
subsequently
confirmed  elsewhere (Barbeau, 1985;25 Tanner, 1985). Analysis of all
early
age  onset IPD (EPD) cases born and raised in Saskatchewan revealed that
20
of  22  had  exclusively  rural exposure during the first 15 years of
life.
This  distribution  was significantly different from the general
population
(p  =  0.0141).  Further study of the EPD group included sampling and
metal
analysis  of childhood sources of drinking water in 18 cases and 36 age
and
sex-matched  controls. Water collected from the two groups was analyzed
for
23  metals  (including 7 elements implicated in the etiology of IPD).
There
was  no  difference  in  the metal composition of the water between the
two
groups.  Finally,  a  review of herbicide and pesticide use in
Saskatchewan
agriculture was undertaken to determine if there was an increased
incidence
of  EPD  following  utilization of any particular chemical. No increase
was
found  in  the  incidence  of EPD with the introduction of any pesticide
or
herbicide, including Paraquat, for agricultural use. We conclude that
there
is  a strong correlation between early age rural environmental exposure
and
development  of  IPD.  We  believe  well  water is a likely vehicle for
the
causal  agent,  but  neither  water  metal  concentration  nor  any  of
the
herbicides  and  pesticides used in Saskatchewan agriculture are related
to
the cause.
  Tags: Human
  Descriptors:  *Environmental  Pollution--Adverse Effects--AE;
*Herbicides
--Adverse  Effects--AE; *Parkinson Disease, Symptomatic--Chemically
Induced
--CI; *Pesticides--Adverse Effects--AE; *Water Pollution,
Chemical--Adverse
Effects--AE;  Adult;  Canada;  Middle  Age;  Parkinson Disease,
Symptomatic
--Epidemiology--EP;  Parkinson Disease, Symptomatic--Etiology--ET
  CAS Registry No.: 0   (Herbicides); 0   (Pesticides)
 
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06178651   87152651
  Early onset Parkinson's disease and childhood environment.
  Rajput AH; Uitti RJ; Stern W; Laverty W
  Adv Neurol (UNITED STATES)   1987,  45 p295-7,  ISSN 0091-3952
Journal Code: 2NX
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 8706
  Subfile:   INDEX MEDICUS
  Tags: Human; Support, Non-U.S. Gov't
  Descriptors: *Parkinson Disease--Etiology--ET; *Social Environment;
Adult
; Aged; Follow-Up Studies; Middle Age; Risk; Rural Population;
Saskatchewan
; Urban Population
 
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06077110   87051110
  Early    onset   Parkinson's   disease   in
Saskatchewan--environmental
considerations for etiology.
  Rajput AH; Uitti RJ; Stern W; Laverty W
  Can J Neurol Sci (CANADA)   Nov 1986,  13 (4) p312-6,  ISSN 0317-1671
Journal Code: CJ9
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 8703
  Subfile:   INDEX MEDICUS
  The  cause  of idiopathic Parkinson's Disease (PD) is not known but it
is
believed  to  be  related  to  some  environmental  agent(s).  Given a
long
preclinical  interval  and  onset of symptomatology around age 60 years,
it
becomes  impossible to identify and analyze all prior environmental
factors
satisfactorily. To circumvent these difficulties we evaluated the
childhood
environment  in  those  PD patients whose symptoms began at age 40 years
or
earlier.  Twenty-one  such  cases  were  born and raised in the province
of
Saskatchewan.  Nineteen  of  these  21 patients spent the first 15 years
of
life  exclusively  in  rural  Saskatchewan.  Detailed  population
analysis
indicates  a  strong  predisposition  to early onset idiopathic
Parkinson's
Disease (EPD) in those raised in rural areas (p = 0.0154). All but one
case
utilized  exclusively  well  water  for the first 15 years of life--a
trait
significantly different from that expected in the provincial population.
It
is  concluded  that  rural  Saskatchewan environments contribute to EPD
and
that  well  water  used  in  childhood  should be considered as a
potential
vehicle for the etiological agent.
  Tags: Human; Support, Non-U.S. Gov't
  Descriptors: *Parkinson Disease--Etiology--ET; *Water Supply; Age
Factors
;  Environment; Parkinson Disease--Epidemiology--EP; Retrospective
Studies;
Rural Population; Saskatchewan; Urban Population
 
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05746779   86047779
  Measles infection and Parkinson's disease.
  Sasco AJ; Paffenbarger RS Jr
  Am  J  Epidemiol (UNITED  STATES)   Dec  1985,  122  (6)  p1017-31,
ISSN
0002-9262   Journal Code: 3H3
  Contract/Grant No.: CA 25264
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE
  JOURNAL ANNOUNCEMENT: 8602
  Subfile:   INDEX MEDICUS
  A   case-control  analysis  of  Parkinson's  disease  and  infections
 in
childhood  was  conducted  in  a  cohort of 50,002 men who attended
Harvard
College  (Cambridge,  MA)  or the University of Pennsylvania
(Philadelphia,
PA)  between 1916 and 1950 and who were followed in adulthood for
morbidity
and  mortality  data.  Cases  of  Parkinson's  disease were identified
from
responses  to  mailed  questionnaires  and death certificates through
1978.
Four  controls  from  the  same  population  were selected for each
case. A
reduced  risk  of  Parkinson's  disease  was associated with most
childhood
viral  infections.  The  negative association was statistically
significant
for  a  history of measles prior to college entrance (exposure odds
ratio =
0.53;  95%  confidence limits: 0.31, 0.93). The reduced risk of
Parkinson's
disease  among subjects with a positive history of measles in childhood
may
reflect  an  adverse  effect  of  measles in adulthood or of subclinical
or
atypical measles. Furthermore, a negative history of measles, especially
if
associated  with  a  lack  of  other common diseases, could be a marker
for
negative  influenza history before 1918 and thus a higher risk of
infection
during  the  1918  influenza  epidemic,  because  of  the  lack  of
partial
influenza  immunity.  These data may also suggest a truly protective
effect
of  measles, compatible with some complex interaction between measles
virus
and the virus of the 1918 influenza epidemic.
  Tags: Human; Male; Support, Non-U.S. Gov't; Support, U.S. Gov't,
P.H.S.
  Descriptors:  *Measles--Complications--CO;  *Parkinson
Disease--Etiology
--ET; Adolescence; Adult; Aged; Child; Child, Preschool; Death
Certificates
; Epidemiologic Methods; Infant; Influenza--Complications--CO;
Longitudinal
Studies;  Massachusetts;  Measles--Epidemiology--EP;  Middle Age;
Parkinson
Disease--Epidemiology--EP;  Parkinson Disease--Mortality--MO;
Pennsylvania;
Questionnaires; Regression Analysis; Risk
 
_======================================================================
 
Hopes this is helpful.
 
Best,
 
Bob
 
--
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Robert A. Fink, M. D., F.A.C.S.   Phone: 510-849-2555
Neurological Surgery              FAX:  510-849-2557
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