Sharon & Jim LeBlanc wrote:
> Could you pass this on to the group so maybe someone out there can figure
> this out .
> thanks. [log in to unmask]

> Hi Judy, Nice job with the information. Co Q10 is only one piece of a big
> complex called Complex I or NADH-Ubiquinone oxioreductase. Complex I is the
> first step in the electron transport chain of mitochondrial oxidative
> phosphorylation and is located within the mitochondrial inner membrane. It
> accepts electrons from NADH and transfers them through a series of electorn
> carriers to ubiquinone (Coenzyme Q10). The internal electron carriers of
> Complex I include flavin mononucleotide (FMN) and 6 iron-sulfur clusters .
> Rotenone, an herbicide, causes Parkinsons symptoms, is thought to interact
> with the ubiquinone binding site.
> OMIN #516000 Complex I, Subunit ND1; MTND1 .
>
>  NDUFV2 is a Complex I gene, polypeptide 24kD, and causes Parkinsons
> disease. UQCRFS1 Human Rieske FE-S Protein is another gene mutation of
> Complex I that causes Parkinsons. It is part of the 6 iron-sulfur clusters.
>  There are several complexes actually in this reaction. I am interested in
> complex I and II. I am interested in information about NAD. My husband has
> Parkinsons color blindness (tritanopia blue-yellow). He can never tell the
> difference between blue and green. NAD  Nicotinamide adenine dinucleotide
> effects your eyes and NADH  Nicotinamide dehydrogenase is part of complex
> one.  Nicotinamide-nucleotide adenylyltransferase is an enzyme that
> catalyzes the transfer of the adenylyl moiety of adenosine triphosphate to
> the phosphoryl group nmn to form NAD and pyrophosphate. B vitamins are
> pyrophosphalated and are messed up in Parkinsons. Nicotinic acetylcholine
> receptors contains an ion channel as a result of binding to acetylcholine
> and initiates muscle contractions. Imidoesters form amides like
> nicotinamide and are part of uric acid. People with high uric acid are less
> likely to get Parkinsons. Complex I is NADH-ubiquione oxioreductase.
> Complex II or succinate-ubiquione oxioreductase is an important enzyme in
> both the tricarboxylic acid cycle  (this is how viagra works) and the
> aerobic respiratory chain of mitochondria, Complex I, II, III, IV ect. It
> is specifically involved in succinate and carries electrons from FADH
> flavin adenosine dehydrogenase to ubiquinone. Now in Parkinsons Disease the
> FAD is not working right either. FAD connects to glutathione reductase, and
> to A2Red and P450 or CYP2D6 and thioredoxin all of which are problems for
> parkinsonians.  And succinate becomes succinyl choline which relaxes
> muscles and stops them from contracting, it is a cholinergic antagonist and
> is not working either.   Carbaryl is an insecticide that effects adenosine
> monophosphate. Nicotine helps Parkinsonians. I'm wondering if the problem
> really is the adenyl moiety of adenosine triphosphate? Or not enough
> nicotinamide-nucleotide adenylyltransferase?

--
Judith Richards, London, Ontario, Canada
<[log in to unmask]>
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